Metformin promotes susceptibility to experimental Leishmania braziliensis infection
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چکیده
منابع مشابه
The susceptibility of domestic cats (Felis catus) to experimental infection with Leishmania braziliensis.
Over the last few years, several cases of feline leishmaniasis (FL) with cutaneous and visceral forms have been reported around the world. Nonetheless, the real susceptibility of cats to infection with Leishmania spp. and the outcome of leishmaniasis in these animals are poorly understood. Experimental studies on feline models will contribute to the knowledge of natural FL. Thus, in order to de...
متن کاملThe immunobiology of Leishmania braziliensis infection
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L. braziliensis, a New World representative of the Leishmania genus, has been the least studied. Although leishmaniasis caused by L. braziliensis induces a range of clinical manifestations ranging from mild ...
متن کاملImmunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection
BACKGROUND Previous works showed that immunization with saliva from Lutzomyia intermedia, a vector of Leishmania braziliensis, does not protect against experimental infection. However, L. braziliensis is also transmitted by Lutzomyia whitmani, a sand fly species closely related to Lu. intermedia. Herein we describe the immune response following immunization with Lu. whitmani saliva and the outc...
متن کاملEnhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva
BACKGROUND Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection. In the present study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L. braziliensis infection employing an intradermal e...
متن کاملLeishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice.
Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-gamma) deficient (-/-) mice in...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2020
ISSN: 1678-8060,0074-0276
DOI: 10.1590/0074-02760200272